There is an increasing number of young people suffering from connective tissue diseases. If treatment is ineffective, disease progression may occur. It can be expressed in change in gait, pain and irreversible changes in joints, skin, kidneys, heart, lungs. This changes in heart, lungs and kidneys can cause heart, renal and respiratory failure. This leads to disability of the patient, decrease in quality of life. It is very important to see doctor at the first signs of illness.